Much of Sedaris's humor is ostensibly autobiographical and self-deprecating and often concerns his family life, his middle-class upbringing in the suburbs of Raleigh, North Carolina, his Greek heritage, homosexuality, jobs, education, drug use, and obsessive behaviors, as well as his life in France, London, New York, and the South Downs in England. He is the brother and writing collaborator of actress Amy Sedaris.
