Born to a working-class family in Oldham, in the north of England, and a full-time art student on scholarship by age 13, Clarke came to prominence in the late 1970s as a painter and figure of the Punk movement and designer of stained glass. By the early 1980s he had become a major figure in international contemporary art, the subject of several television documentaries and a café society regular. He is known for his architectonic art, prolific output in various media, friendships with key cultural figures, and polemical lectures and interviews.
His practice in architectural and autonomous stained glass, often on a monumental scale, has led to successive innovation and invention in the development of the medium. the origination of techniques allowing the inclusion of two colours in a single sheet of opaque glass, and the development of bonding techniques including multi-lamination.}} This includes the creation of stained glass without lead and the subsequent pioneering of a 'dramatically enhanced Pointillism' in glass, as well as the creation of sculptural stained glass works, analogous to collage, made primarily or entirely of lead. The latter two advances are described as having taken stained glass as an art form to its zero-point in each direction: absolute transparency and complete opacity.}}