Her family arranged several marriages for her that advanced their own political position including Giovanni Sforza, Lord of Pesaro and Gradara, Count of Cotignola; Alfonso of Aragon, Duke of Bisceglie and Prince of Salerno; and Alfonso I d'Este, Duke of Ferrara. Alfonso of Aragon was an illegitimate son of the King of Naples and tradition has it that Lucrezia's brother Cesare Borgia may have had him murdered after his political value waned.
Rumors about her and her family cast Lucrezia as a ''femme fatale'', a role in which she has been portrayed in many artworks, novels and films.